×
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
[Mutation of isocitrate dehydrogenase 2 (IDH2) gene in Chinese AML patients and its clinical significance].
23815907 2013
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
[FMS-like tyrosine kinase 3 gene mutations in acute myeloid leukemia].
19840437 2009
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
[Analysis of DNMT3a gene mutations in acute myelogenous leukemia].
21518476 2011
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
WT1 vaccination in acute myeloid leukemia: new methods of implementing adoptive immunotherapy.
24521058 2014
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
WT1 overexpression affecting clinical outcome in non-hodgkin lymphomas and adult acute lymphoblastic leukemia.
24374862 2014
×
Entrez Id: 7490
Gene Symbol: WT1
WT1
Leukemia, Myelocytic, Acute
0.700
GeneticVariation
CLINVAR
Wilms' Tumour 1 (WT1) peptide vaccination in patients with acute myeloid leukaemia induces short-lived WT1-specific immune responses.
24422723 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
15256420 2004
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
22504184 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
22504184 2012
×
Entrez Id: 7307
Gene Symbol: U2AF1
U2AF1
Leukemia, Myelocytic, Acute
0.470
GeneticVariation
CLINVAR
U2AF1 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.
23029227 2012
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
The role of mutations in epigenetic regulators in myeloid malignancies.
22898539 2012
×
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
The role of mutations in epigenetic regulators in myeloid malignancies.
22898539 2012
×
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
The role of mutations in epigenetic regulators in myeloid malignancies.
22898539 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia.
23714533 2013
×
Entrez Id: 3815
Gene Symbol: KIT
KIT
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia.
23714533 2013
×
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A
Leukemia, Myelocytic, Acute
0.800
CausalMutation
CLINVAR
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers.
24656771 2014
×
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation.
21596855 2011
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
GeneticVariation
CLINVAR
The other novel mutation, FLT3 K663Q, is the first AML -associated gain-of-function mutation located outside the JM and AL domains.
16990784 2006
×
Entrez Id: 3717
Gene Symbol: JAK2
JAK2
Leukemia, Myelocytic, Acute
0.800
GeneticVariation
CLINVAR
The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML.
22829971 2012
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia.
23783394 2013
×
Entrez Id: 3418
Gene Symbol: IDH2
IDH2
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.
23558173 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Leukemia, Myelocytic, Acute
0.700
CausalMutation
CLINVAR
Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.
24803665 2014
×
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
Leukemia, Myelocytic, Acute
1.000
CausalMutation
CLINVAR
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
22368270 2012
×
Entrez Id: 23451
Gene Symbol: SF3B1
SF3B1
Leukemia, Myelocytic, Acute
0.500
GeneticVariation
CLINVAR
SF3B1 mutation is a rare event in Chinese patients with acute and chronic myeloid leukemia.
23395771 2013
×
Entrez Id: 3716
Gene Symbol: JAK1
JAK1
Leukemia, Myelocytic, Acute
0.430
GeneticVariation
CLINVAR
Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression.
21436584 2011